美沙拉嗪联合康复新液灌肠对溃疡性结肠炎患者血清hs-CRP和IL-6的影响

The effectiveness of mesalazine plus rehabilitation liquid enema on serum hs-CRP and IL-6 in patients with ulcerative colitis

目的探讨美沙拉嗪联合康复新液灌肠对溃疡性结肠炎患者血清超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)的影响。方法 100例溃疡性结肠炎患者随机分为两组,观察组50例,对照组50例,对照组采用柳氮磺胺吡啶(SASP)治疗,观察组采用美沙拉嗪联合康复新液灌肠。两组共治疗8周后分析疗效。测定患者血清hs-CRP和IL-6。结果观察组总疗效为96%,对照组总疗效为84%,两组比较有明显差异(P<0.05)。两组治疗后患者血清hs-CRP和IL-6均有明显降低,并且与对照组治疗后比较,观察组降低更明显(P<0.05)。结论美沙拉嗪联合康复新液灌肠可以更明显抑制溃疡性结肠炎患者的炎症反应。

Objective To study the effectiveness of mesalazine plus rehabilitation liquid enema on serum high-sensitivity C-reactive protein（hs-CRP） and interleukin-6（IL-6） in patients with ulcerative colitis.Methods 100 patient with ulcerative colitis were randomly divided into two groups,the observtion group（n=50 cases） and the contol group（n=50 cases）.The patients in the control group were treated through sulfasalazine,while the patients in the observation group were treated through mesalazine plus rehabilitation liquid enema.They were all treated for eight weeks.Serum hs-CRP and IL-6 were detected before and after treatment.Results The total effects were 96% of the observation group and 84% of the control group,the two groups were significantly different（P ＆lt;0.05）.After treatment,patients with serum hs-CRP and IL-6 were significantly reduced compared with the control group after treatment,the observation group decreased significantly（P ＆lt;0.05）.Conclusions Mesalazine plus rehabilitation liquid enema can significantly Inhibit the inflammatory response of patients with ulcerative colitis.