营养不良、反复呼吸道感染患儿微量元素锌、铅含量研究

Study zinc and lead on the children with malnutrition and recurrent respiratory infection

目的研究营养不良、反复呼吸道感染（recurrent respiratory infection，RRI）患儿的锌、铅含量情况．为临床诊治营养不良与RRI患儿提供参考依据。方法对2009年3月-2013年3月在我院诊断为营养不良的患儿300例（营养不良组），RRI患儿300例（RRI组），营养不良合并RRI患儿300例（营养不良＋RRI组）及健康体检儿童300例（对照组）进行血清锌、铅含量的定量检测，并对数据进行统计分析。结果营养不良组、RRI组及营养不良＋RRI组中锌缺乏、铅中毒的患儿比率均显著高于对照组，经比较差异均有统计学意义（P均〈0．05）。营养不良组、RRI组及营养不良＋RRI组间比较，营养不良＋RRI组锌缺乏、铅中毒的患儿比率均高于营养不良组和RRI组，差异均有统计学意义（P均〈0．05）。结论营养不良及RRI均可引起患儿锌缺乏和铅中毒，且两种疾病同时存在时锌缺乏和铅中毒的情况更加严重。在补锌的同时，排铅也应引起重视．以改善患儿的营养与免疫力。

Objective To study the zinc and lead on the children with malnutrition and recurrent respiratory infection （RRI）, and provide evidence for the clinical treatment of malnutrition and RRI. Methods 300 cases children with malnutrition （malnutrition group ）, 300 cases children with RRI （RRI group）, 300 cases children with malnutrition combined RRI （malnutrition＋RRI group ）, and 300 cases healthy children （control gorup） were collected in our hospital from March 2009 to March 2013. Serum zinc and lead in all groups were detected, and the data were analyzed. Results The rates of patients with lack of zinc and lead poisoning in malnutrition group, RRI group and malnutrition ＋RRI group, were all higher than in control group, and the differences all had statistical significance （Pall〈 0.05）. In these three groups, the rates of patients with lack of zinc and lead poisoning in malnutrition＋RRI group were all higher than in malnutrition group and RRI group, and the differences all had statistical significance（Pall〈 0.05）. Conclusion Malnutrition and RRI all can result in lack of zinc and lead poisoning. And the situation is serious when patient with malnutrion＋RRI. Zinc supply in children with malnutrition and RRI, and the lead should be take seriously to cut down, to improve children＇s nutrition and immunity.