拉氧头孢静滴后飞行员少量饮酒出现戒酒硫样反应1例报告

Small amount of alcohol drinking induced disulfiram-like reaction in pilots during intravenous drip of cephalosporins

目的总结戒酒硫样反应的诊治经验。方法回顾我院2010年4月1例使用头孢类抗生素期间的飞行员少量饮用啤酒引起戒酒硫样反应的诊治过程。患者直升机飞行员,男,31岁。输尿管镜下钬激光碎石取石术后给予拉氧头孢1.0 g 2/d静滴。术后第5日,患者晚饭时饮用一瓶啤酒后1 h,自觉头晕、胸闷、嗜睡、醉酒感明显。血压80/30 mmHg(1 mmHg=0.133 kPa),心率110/min。结果根据患者使用药物史、少量饮酒史、症状、体征及检查结果,诊断为戒酒硫样反应。给予输液、吸氧、糖皮质激素等治疗后症状消失。结论使用头孢类抗生素期间少量饮酒即可引起戒酒硫样反应。

Objective To summarize the experience in diagnosis and treatment of disulfiram-like reaction. Methods The diagnosis and treatment of a small amount of beer drinking induced disulfiram-like reaction in a pilot during intravenous drip of cephalosporins were retrospectively anlyzed. The patient was a male helicopter pilot aged 31 years. After ureteroscopic holmium laser lithotripsy, he was treated with cephalosporins （1.0 g, twice a day）. He complained of dizzy, chest distress, sleepiness, and drunkenness I hour after he drank a bottle of beer at supper. His blood pressure was 80/30 mmHg （1 mmHg--0.133 kPa） and his heart rate was I l0 beats/min. Results He was diagnosed as disulfiram-like reaction according to his history of drug use and a small amount of alcohol drinking, symptoms, signs and ECG. After treated with parental fluid, oxygen inhalation and glucocorticoid, his symptoms disappeared. Conclusion A small amount of alcohol drinking can immediately induce disulfiram-like reaction in pilots during intravenous drip of cephalosporins.