血清RhoA与2型糖尿病及其血管并发症的相关性研究

The relationship between RhoA and type 2 diabetes mellitus and its angiopathy

目的探讨RhoA与2型糖尿病（T2DM）及其血管并发症之间的关系。方法入选研究对象160例，其中对照组40例，单纯2型糖尿病组40例，2型糖尿病血管并发症组80例。应用酶联免疫吸附试验（ELISA）测定其RhoA浓度，同时检测血糖、血脂、胰岛素、糖化血红蛋白（HbAlc）等指标水平。结果单纯2型糖尿病组患者血清RhoA水平为（9．91±3．41）ng／ml，明显高于对照组[（4．77±1．92）ng/m1]；2型糖尿病血管并发症组患者RhoA水平为（21．27±7．00）ng/ml，明显高于对照组和单纯2型糖尿病组（P均〈0．05）。Logistic回归分析结果显示，RhoA、糖尿病家族史、体重指数、三酰甘油、总胆固醇及低密度脂蛋白胆固醇是2型糖尿病的独立危险因素，RhoA、年龄、吸烟史、HbAlc、总胆固醇及低密度脂蛋白胆固醇是2型糖尿病血管并发症的独立危险因素。结论血清RhoA升高有可能成为预测糖尿病及其血管并发症发生风险的指标之一。

Objective To investigate the association between RhoA and type 2 diabetes mellitus （T2DM）and its angiopathy. Methods The normal control group（group A,n =40） ,the T2DM group （ group B, n = 40 ） and the type 2 diabetic angiopathy group （ group C, n = 80 ） were selected. Fasting plas- ma RhoA, blood glucose, blood lipids, insulin and glycosylated hemoglobin （ HbAlc ） were detected. Results The serum level of RhoA in group B was （9.91 ＋ 3.41 ）ng/ml and markedly higher than（4.77 ＋ 1.92）ng/ml in group A. The RhoA in group C was（21.27 ＋-7.00）ng/ml and significantly higher than that in the group A and B （ all P 〈 0.05 ）. Logistic analysis showed that RhoA, diabetic family history, body mass index, triglyceride, total cholesterol （ TC）, low-density lipoprotein cholesterol （LDL-C） were the inde- pendent risk factors for T2DM. RhoA, age, smoking history, HbA1 c,TC, LDL-C were the independent risk factors for T2DM vascular complications. Conclusion High serum level of RhoA may be a predictive fac- tor of the risk of T2DM and its vascular complications.