光交联N-丙烯酰氨基葡萄糖/PEGDA水凝胶的制备及表征

Preparation and Characterization of Photo-Crosslinked N-Acryloyl-Glucosamine / Poly( Ethylene Glycol) Diacrylate Hydrogels

采用紫外光交联技术制备可原位成型的N-丙烯酰氨基葡萄糖(AGA)/聚乙二醇双丙烯酸酯(PEGDA)水凝胶.通过核磁共振氢谱考察凝胶成型过程中AGA/PEGDA体系组成的变化,采用傅里叶变换红外光谱、X射线光电子能谱、扫描电子显微镜等表征了冷冻干燥凝胶的化学组成和表面形貌,同时考察了光引发剂质量浓度、AGA和PEGDA用量对水凝胶溶胀率和交联产率的影响.结果表明:氨基葡萄糖单元被成功引入到PEGDA凝胶网络中;光引发剂质量浓度为0.6 g/L时,AGA/PEGDA体系的交联产率最佳;AGA用量增加会引起体系交联产率下降,而随PEGDA用量增加,体系交联产率呈先下降后升高的趋势;AGA和PEGDA用量的增加都会导致凝胶溶胀率下降,AGA用量的增加还将使凝胶表面出现皱褶.

N-acryloyl-glucosamine （AGA） and poly （ ethylene glycol） diacrylate （PEGDA） were used to prepare hydrogels via an in-situ forming procedure with photopolymerization, and 1H NMR was employed to reveal the com- position variation of AGA/PEGDA system during the gelation. Then, the chemical composition and morphology of lyophilized hydrogels were evaluated by means of FT-IR, XPS and SEM, and the effects of photoinitiator mass con- centration, AGA dosage and PEGDA dosage on the swelling ratio and the crosslinking yield were investigated. The results indicate that glucosamine is successfully incorporated into PEGDA hydrogel network, that the erosslinking yield reaches the maximum at a photoinitiator content of 0.6 g/L, that the crosslinking yield of hydrogels decreases with the increase of AGA dosage but decreases first and then increases with the increase of PEGDA dosage, that the swelling ratio of hydrogels decreases with the increase of AGA and PEGDA dosages, and that a shrinking surface may occur at high AGA dosage.