阿昔洛韦壳聚糖滴眼液的制备及眼部滞留性考察

Preparation and ocular retention of aciclovir chitosan eye-drops

目的研制阿昔洛韦(ACV)-壳聚糖(CS)滴眼液,以延长阿昔洛韦的眼部滞留性。方法以CS为增黏剂制备ACV-CS滴眼液,并对其性状、黏度、pH值、含量、稳定性等进行检测;以家兔为实验动物,分别考察ACV-CS滴眼液的眼部滞留性和眼部刺激性。结果 ACV-CS滴眼液的性状、黏度、pH值、含量、稳定性等均符合要求;与普通ACV滴眼液相比,ACV-CS滴眼液的黏性(1.8×10^(-2) Pa·s)显著增加,对兔眼部无明显刺激性,刺激反应评分为0.25,并显著延长眼部滞留时间(60 min以上)。结论本品制备简单,使用安全,具有较好的眼部滞留作用,值得进一步研究。

Objective To study acyclovir （ACV） eye-drops by using chitosan （CS） as the adhesive to prolong the ocular retention. Methods The formula and preparation process of the eye-drops were made, and the quality including appearance,viscosity,pH,concentration and stability was studied. Rabbits as the testing animals,the eye irritation and retention were also observed. Results Compared with that of common ACV eye-drops, the viscosity of ACV-CS eye-drops increased significantly （ 1. 8 x 10 2 Pa ＇ s）, and the ocular retention was prolonged （ above 60 min） without any irritation （ irritation score of 0.25 ）. Conclusion ACV-CS eye-drops are promising with the properties of easy preparation, safe application and prolonged ocular retention.