正丁基苯酞的合成及结构表征

Synthesis and characterization of n-butylphthalide

目的合成正丁基苯酞并对其结构进行表征。方法以邻甲酰基苯甲酸为原料与格氏试剂进行反应,研究不同投料比对反应产率的影响,并通过质谱、紫外可见光谱、红外光谱、核磁共振氢谱表征反应产物结构。结果邻甲酰基苯甲酸与格氏试剂投料比为1:2.5时的产率最高,达49%。反应产物经确证为正丁基苯酞。结论本方法安全性高、原料成本低、步骤简便易行。

Objective To synthetise and characterize n-butylphthalide. Methods n-butylphthalide was synthesized via 2-earboxybenzaldehyde and Grignard reagent, and the product was confirmed by ESI-MS,UV, IR and H-NMR. Results A 49% yield is the highest when the materials ratio between 2-carboxybenzaldehyde and Grignard reagent is l ： 2.5. After determination, the reaction product is n-butylphthalide. Conclusion This method is of high safety, low cost of raw materials, convenient and feasible.