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DMPP对于鸡胚血管形成的抑制作用 被引量：2

Inhibitory effect of DMPP in the angiogenesis of chick embryo
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摘要 目的研究1,1-二甲基-4-苯基哌嗪(1,1-dimethyl-4-phenyl piperazinium,DMPP)对于鸡胚发育期血管新生的作用。方法采用质量浓度为50μg/mL的DMPP溶液局部处理鸡胚绒毛尿囊膜(chickenchorioallantoic membrane,CAM)和鸡胚卵黄囊膜(yolk sac membrane,YSM)表面,分别用肉眼和显微镜观察与被测物作用后CAM膜上血管生成情况和YSM膜血管密度和生长率的变化。结果 DMPP能明显抑制CAM模型血管的生成和YSM模型的血管面积和密度的增长。结论 DMPP可抑制鸡胚血管的形成。 Objective To investigate the role of 1,1-dimethyl-4-phenylpiperazinium （DMPP）in the angiogcnesis of early chick embryo. Methods The chicken chorioallantoie membrane （CAM） and yolk sac membrane （YSM） were treated with 50 μg/mL DMPP. The angiogenesis of CAM was observed visually. The vascular density and growth rate of YSM were examined by microscopy. Results DMPP obviously suppressed the angingenesis of CAM and decreased the vascular density and growth rate of YSM. Conclusion DMPP exhibits an inhibitory eflbet on the augiogenesis of chicken embryo.
作者 周秦 何晓东 亓翠玲 李江超 郭四美 叶杰 韩露 王丽京
机构地区 广东药学院基础学院
出处 《广东药学院学报》 CAS 2013年第3期322-325,共4页 Academic Journal of Guangdong College of Pharmacy
基金 国家自然科学基金面上项目(31271455)
关键词 DMPP 鸡胚绒毛尿囊膜 鸡胚绒毛卵黄囊膜 血管形成 DMPP chicken chorioallantoic membrane yolk sac membrane angiogenesis
分类号 R965 [医药卫生—药理学]
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参考文献16

  • 1RISAU W.Mechanisms of angiogenesis[J].Nature,1997,386 (6626):671-674.
  • 2FERRARA N,ALITALO K.Clinical applications of angiogenic growth factor and their inhibitors[J].Nat Med,1999,5(12):1359-1364.
  • 3HANAHAN D,WEINBERG R A.Hall marks of cancer:the next generation[J].Cell,2011,144 (2):646-674.
  • 4PRADO W A,SEGALLA D K.Antinociceptive effects of bethanechol or dimethylphenylpiperazinum in models of phasic or incisional pain in rats[J].Brain Res,2004,1018(2):272-282.
  • 5KAWA K.Inhibitory synaptic transmission in area postrema neurons of the rat showing robust presynaptic facilitation mediated by nicotinic Ach receptors[J].Brain Res,2007,1130(1):83-94.
  • 6CHERDCHU CHEXUM T D.Characterization of 1,1-dimethyl-4-phenylpiperazinium induced increased proenkephalin processing in bovine chromaffin cells[J].Life Sci,1988,43(13):1069-1077.
  • 7何彦清,李艳,王晓钰,等.DMPP对早期鸡胚血管发生的影响[OL].中国科技论文在线,http://www.docin.com/p-494423153.html,20120921.
  • 8RIBATTI D,VACCA A,RONCALI L,et al.The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis[J].Int J Dev Biol,1996,40 (6):1189-1197.
  • 9CHAN T,BURGGREN W.Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus)[J].Respir Physiol Neurobiol,2005,145(2):251-263.
  • 10IE NOBLE F,MOYON D,PARDANUAD L,et al.Flow regulates arterial-venous differentiation in the chick embryo yolk sac[J].Development,2004,131 (2):361-375.

二级参考文献9

共引文献6

同被引文献26

  • 1张斌,阮喜云,陈杰,张士宝,刘双庆,王全颖,杨广笑,刘庆勇.人肾癌鸡胚模型的建立及其肿瘤生物学特性的研究[J].西安交通大学学报（医学版）,2012,33(1):68-70. 被引量：7
  • 2Hagedorn M, Javerzat S, Gilges D, et al. Accessing key steps of human tumor progressionin vivo by using an avian embryo model [J]. Proc Natl Acad Sci U S A, 2005, 102(5) : 1643-1648.
  • 3Risan W. Mechanisms of angiogenesis [J]. Nature, 1997, 386 (6626) : 671-674.
  • 4Dai C, Celestino JC, Okada Y, et al. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo [J]. Genes Dev, 2001,15(15) : 1913-1925.
  • 5Holland EC, Celestino J, Dai C, et al. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice [J]. Nat Genet, 2000, 25(1) : 55-57.
  • 6Reilly KM, Loisel DA, Bronson RT. Nfl ;Trp53 mutant mice de- velop glioblastoma with evidence of strain-specific effects [ J ]. Nat Genet, 2000, 26(1) : 109-113.
  • 7Aldhous P, Coghlan A, Copley J. Animal experiments -- where do you draw the line?: Let the people speak [J]. New Sci, 1999, 162(2187) : 26-31.
  • 8Hagedorn M, Zilberberg L, Wilting J, et al. Domain swapping in a COOH-terminal fragment of platelet factor 4 generates potent an- giogenesis inhibitors [ J ]. Cancer Res, 2002, 62 ( 23 ) : 6884- 6890.
  • 9RisauW. Mechanisms of angiogenesis [ J ]. Nature, 1997, 386 (6626) : 671-674.
  • 10Ribatti D, Vacca A, Costantino F, et al. Exogenous heparin in- duces fibronectin overexpression parallel to angiogenesis in the ex- tracellular matrix of the chick embryo chofioallantoic membrane [J]. Tissue Cell, 1997, 29(2) : 131-136.

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广东药学院学报
2013年 第3期

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