摘要
心室重构是多种心血管疾病发展到慢性心功能不全的重要病理基础,基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)能降解细胞外基质,在细胞外基质胶原重构过程中具有重要作用,而钙离子是细胞内第二信使,与多种细胞的生物功能相关。近年来研究表明,钙离子与MMP-9所致心室重构相关。本文就钙离子在MMP-9相关心室重构中的作用予以综述。
Ventricular remodeling is an important pathological basis of chronic cardiac insufficiency including a variety of cardiovascular diseases. Matrix metalloproteinase 9 （MMP9） plays a critical role in e^tracellular matrix remodeling by degradation of the extracellular matrix. Calcium ion shows an essential biological function in various cells as second messenger. Recent studies ventricular remodeling. This paper will review the remodeling. report that calcium ion is involved in MMP9-associated role of calcium ion in MMPg-associated ventricular
出处
《广东药学院学报》
CAS
2013年第3期345-347,F0003,共4页
Academic Journal of Guangdong College of Pharmacy
关键词
基质金属蛋白酶-9
心室重构
钙离子
matrix metalloproteinase 9
ventricular remodeling
calcium ion
