肠道转运体在药物吸收中作用的研究进展

Progress on the role of intestinal transporters in drug absorption

口服药物的生物利用度与肠道吸收密切相关。肠道中存在多种药物转运体参与药物的吸收、分布、代谢及排泄。研究转运体在吸收中的作用对提高药物的生物利用度及避免临床药物相互作用具有重要意义。本文对肠道主要药物转运体的功能及其在药物吸收中的作用进行综述。

The bioavailability of oral drug is closely related to the intestinal absorption.There are a variety of intestinal transporters involved in drug absorption,distribution,metabolism and elimination.It is great significant to study the role of transporters in the drug absorption,which will improve the bioavailability of drugs and avoid clinical drug interaction.This paper will review the function of intestinal drug transporters and their roles in drug absorption to provide evidence for further study.