广州汉族葡萄膜炎患者转化生长因子TGFβ1-509C／T基因多态性研究

Relationship of Polymorphism of TGFβ1-509C/T with Uveitis of Han Popunation in Guangzhou

目的 探讨转化生长因子β1（TGBβ1）-509C/T基因多态性与葡萄膜炎病的关系.方法 运用多聚酶链反应技术检测广州汉族75例葡萄膜炎及140例正常人转化生长因子TGFβ1-509C/T基因多态性的分布.结果 葡萄膜炎组转化生长因子TGFβ1-509C/T基因多态性基因型频率（%）分别为17.33,42.67和40.00;C,T基因频率（%）分别为0.386 6和0.613 3,而对照组TGFβ1-509C/T基因型频率（%）分别为15.00,44.29和40.71;对照组TGFβ1-509 C,T基因频率（%）分别为0.3714和0.6286;转化生长因子TGFβ1-509C/T基因多态性各种基因型频率在患者组与正常对照组之间的差异无统计学显著性意义（χ2=0.11,P〉0.05）.结论 转化生长因子TGFβ1-509C/T基因多态性与葡萄膜炎无明显相关.

Objectlve To explore relationship of polymorphism of TGFI31-509C/T gene with uveitis of Han popunation in Guangzhou. Methods The genotyes of TGFβ1-509C/T gene were determined by PCR-based assay in 75 patients with uveitis disease and 135 healthy controls. Results The genotepy frequencies of TGFI31-509C/T polymorphism in uveitis group were as follows respectively： 17.33,42.67 and 40. 00. TGFI31-509C,TGFβ1-509T gene frequency： 0. 388 6 and 0. 613 3. The gene frequencies of TGFβ1-509C/T in control group were： 15.00,44. 29 and 40.7. TGF]31-509C, TGFβ1-509T gene frequency： 0. 371 4 and 0. 628 6. There were no significant differences in the frequenceies of TGFβ1-509C/T gene polymorphism be- tween the patients and control groups （Z2 = 0. 11 ,P〉0. 05）. Conclusion No obvious correlation was found between TGFβ1- 509C/T polymorphism and uveitis.