头孢菌素类抗生素皮试液配制方法的研究

Reasearch on the preparation methods about skin-test solution of cephalosporin antibiotics

目的探讨准确、简便的头孢菌素类抗生素皮试液配制方法。方法将0.5 g头孢唑林钠用0.9%氯化钠注射液2 ml稀释后,取0.2 ml加入0.9%氯化钠注射液100 ml中,即可完成皮试液的配制。比较此方法与传统法在皮试液浓度、配制时间以及护士评价的差异。结果改良法配制的皮试液浓度(460.10±43.98)μg/ml,接近目标值500μg/ml,准确性、配制时间和护士评价均优于传统法(P<0.01)。结论改良法配制头孢菌素类抗生素皮试液,浓度准确、耗时少、护士评价好,适合临床推广。

Objective To explore an accurate and simple preparation method of cephalosporin antibiotics skin-test solution.Methods The 0.5 gram cefazolin sodium was diluted by 2 ml 0.9％ sodium chloride injection,then 0.2 ml diluted solution were put in 100 ml 0.9％ sodium chloride injection,which formed the skin-test solution.The concentration,preparation time and nurses＇ evaluation were compared.Results The concentration of the improved method （460.10 ±43.98） μg/ml was close to the target value （500 μg/ml）.The accuracy,preparation time and nurses＇evaluation were significantly better than the traditional method （P ＜ 0.01）.Conclusion The improved method has advantage in accuracy,less time-consuming and higher nurses＇evaluation,thus it is suitable for clinical practice.