摘要
目的:探讨脂蛋白(a)[LP(a)]和胱抑素C(Cys-C)水平测定与2型糖尿病(T2DM)患者的病程、血糖控制水平的关系,以及2型糖尿病患者血清脂蛋白(a)与胱抑素C的相关性。方法:对150例(糖尿病组)患者进行血清LP(a)与Cys-C的水平检测,并与30例体检健康人群(对照组)进行对比分析。150例T2DM患者根据病程分为4组:15年组。结果:糖尿病组的血清LP(a)和Cys-C水平与对照组比较均有显著性差异(P15年组的组间血清LP(a)和Cys-C水平两两比较均有显著性差异(P〈0.05);血清LP(a)和Cys-C水平在T2DM患者中呈显著正相关(r=0.796,P〈0.01)。结论:血清LP(a)和Cys-C是T2DM中引起冠心病(CHD)和糖尿病肾病(DN)的两个独立危险因素,且其检测水平呈正相关。T2DM患者进行血清LP(a)和Cys-C的定期联合检测,能够有效监测和延缓CHD和DN的发生。
Objective:To study the relationship between LP(a) and Cys-C’level and the duration, glycemic control levels in the typeⅡdiabetes. Methods:The detection of LP (a) and Cys-C were analyzed between 150 T2DM patients and 30 healthy people. The 150 T2DM patients were divided into 4 groups according to duration:15 years groups.Results:There were significant difference (P15 years groups. Serum LP (a) and Cys-C levels in patients with T2DM showed a significant positive correlation (r=0.796, P〈0.01).Conclusions:Serum LP (a) and Cys-C are two independent risk factor which could caused coronary heart disease and diabetic nephropathy (DN) , and its detection level was positively correlated. LP (a) and Cys-C combined detection is an effective means of monitoring in T2DM which could delay the incidence of coronary heart disease and DN.
出处
《医学检验与临床》
2013年第4期17-19,共3页
Medical Laboratory Science and Clinics