左卡尼汀对促红细胞生成素治疗血液透析患者贫血的疗效影响

Effects of L - carnitine combined with erythropoietin on renal anemia in maintenance hemodialysis patients

目的观察左卡尼汀对促红细胞生成素(EPO)治疗维持性血液透析(MHD)患者贫血疗效的影响。方法随机选取我院血液净化中心行MHD的慢性肾衰合并贫血患者共50例,分为对照组及试验组。对照组25例,单用EPO治疗,试验组25例,在EPO治疗的同时加用左卡尼汀,试验周期为12周。治疗期末观察各组贫血指标的变化。结果①与治疗前相比,两组的贫血状况均明显改善。②两组之间对比,试验组的血红蛋白(Hb)及红细胞压积(Hct)水平明显高于对照组(P<0.01)。结论 EPO治疗可以改善MHD患者的贫血状况,左卡尼汀可明显提高EPO治疗MHD患者贫血的疗效。

Objective To observe the effect of the L - carnitine combined with erythropoietin on renal anemia in maintenance hemodialysis patients. Methods Fifty maintenance hemodialysis patients with renal anemia in our blood purification center were randomly selected, of which 25 patients were with EPO treatment （ control group） and 25 cases in EPO and L - carnitine treatment group （ experimental group）. All patients were treated for 12 weeks. Then the index of anemia treatment were compared in two groups. Results Anemia condition in both groups was improved compared with that before treatment. The hemoglobin （Hb） and hematokrit （Hct） in the experimental group were significantly higher than those in control group （P 〈 0.01 ）. Conclusion EPO can improve MHD patients with anemia condition. L - carnitine can obviously improve the effect of EPO on maintenance hemodialysis patients with renal anemia.