毛叶香茶菜化学成分研究

Chemical constituents of Isodon Japonica

目的研究毛叶香茶菜Isodon japonica(Burm.f.)Hara叶的化学成分。方法利用反复硅胶柱色谱、重结晶等方法进行分离纯化,并根据理化性质及波谱数据鉴定化合物的结构。结果从毛叶香茶菜叶的70%丙酮提取物的乙酸乙酯萃取部分分离鉴定12个化合物的结构,其中6个为对映贝壳杉烷型二萜即:Enmein(1),Hebeirubescensin K(2),冬凌草甲素(3),Parvifoline G(4),Maoyecrystal A(5),Maoyecrystal L(6);四个三萜即:2α-羟基乌苏酸(7),委菱菜酸(8),Hyptadienic acid(9),2α,3α-二羟基-12-烯-28-乌苏酸(10);一个黄酮:Ladanetin(11);另外一个为β-胡萝卜苷(12)。结论化合物4,8,10,11均为首次从毛叶香茶菜叶中分离得到,化合物11属首次从香茶菜属植物中分离得到。

Objective To study the chemical constituents of the leaves of Isoclon japonica （ Burm L ） Hara. Methods The chemical con- stituents were separated by repeated silica gel column chromatography and their structures were determined by spectral analyses. Results Twelve compounds were obtained and identified, six being ent-kaurane diterpenoids ： Enmein （ 1 ） , Hebeiruhescensin K （ 2 ） , Oridonin （ 3 ）, Parvifoline G （ 4 ）, Maoyecrystal A （ 5 ）, Maoyecrystal L （ 6 ） ; four triterpenes ： 2α-hydroxy-ursolic acid （ 7 ）, Tormentic acid （ 8 ）, Hyptadienic （ 9 ）, 2 α, 3 α-dihydroxyurs-12-en-28-oic acid （ 10 ） ; one fiavone ： Ladanetin （ 11 ） ; the other one β-daucosterol. Conclusion Compounds 4,8,10 and 11 are isolated from Isodonjaponica（ Burro f. ） Hara for the first time. Compound 11 is obtained from the plant of Isodon for the first time.