2型糖尿病患者颈动脉内中膜厚度及斑块形成的相关因素分析

Related factors of carotid intima-media thickness and arteriosclerosis plaque formation in T2DM patients

目的探讨2型糖尿病(T2DM)与颈动脉内中膜厚度(intima-media thickness,IMT)及斑块形成的关系,以及影响IMT和斑块形成的相关因素。方法使用彩色多普勒超声仪对60例T2DM患者及50例正常人(NGT)进行颈部血管彩超检测,对颈总动脉IMT及颈内动脉和颈动脉分叉处的斑块进行比较,并计算IMT厚度和斑块数量;同时比较两组BMI、FPG、HbA1c、TG、TC、HDL-C、LDL-C水平的差异。结果两组病例在年龄、性别、吸烟史差异上无统计学意义(P>0.05),具有可比性。T2DM组颈动脉IMT高于NGT组(P<0.01),两组血管狭窄及斑块分布无明显差异(P>0.05);BMI、FPG、HbA1c、TG、LDL-C与颈动脉IMT呈正相关。结论 T2DM与颈动脉IMT增厚及斑块形成有显著相关性。BMI、FPG、HbA1c、TG、LDL-C是T2DM患者颈动脉IMT增厚和斑块形成的主要影响因素。

Objective To investigate the relationship between carotid artery intima-media thickness （ IMT）, arteriosclerosis plaque forma-tion and type 2 diabetes mellitus, as well as the related influencing factors of IMT and arteriosclerosis plaque formation. Methods We used Doppler ultrasound instrument to detect cervical vessels in 60 eases of T2DM patients and 50 normal controls （NGT）, calculated IMT in common carotid artery and internal carotid artery and counted numbers of plaques. Meanwhile, we compared differences in the lev-els of BMI, FPG, HbA1 c, TG, TC, HDL-C, LDL-C between two groups. Results The carotid artery IMT in T2DM group was significantly higher than that of NGT group （ P 〈 0.01 ）. There was no obvious difference in the two groups in vascular stenosis and plaque distribution （P 〉0.05）. BMI,FPG,HbAlc,TG and LDL-C were positively related to carotid artery IMT. Conclusion BMI,FPG,HbAlc,TG,LDL- C are the main factors affecting carotid IMT thickening and plaquese formation of T2DM patients.