苦参素预防肺结核化疗肝脏损害的临床观察

Clinical observation of oxymatrine in preventing liver injury caused by antitubercular agents

目的观察苦参素预防抗结核药物肝脏损害的临床疗效。方法收集临床诊断活动性肺结核患者186例,随机分为治疗组94例和对照组92例。治疗组在常规化疗的基础上,给予苦参素治疗(苦参素氯化钠注射液),对照组仅给予抗结核化疗。结果治疗组出现肝脏损害6例(6.4%),其中10例乙型肝炎表面抗原阳性患者中有1例(10.0%)出现肝脏损害;对照组出现肝脏损害32例(34.8%)。其中11例乙型肝炎表面抗原阳性患者中有6例(54.5%)出现肝脏损害,两组差异有统计学意义,(P<0.01),提示乙型肝炎表面抗原阳性患者肝功能更易受损害。结论苦参素对预防抗结核药物性肝脏损害临床疗效明确,安全有效。

Objective To explore the clinical effects of oxymatrine in preventing liver injury caused by antitubercular agents. Methods A total of 186 patients confirmed with pulmonary tuberculosis were randomly assigned into treatment group （ n = 94） and control group （ n = 92）. During the conrentional chemotherapy,the treatment group additionally took oxymatrine during the whole course. Results six pa-tients had liver damage in the treatment group （ 6.4% ） ; among the 11 HBsAg positive patients, there was 1 ease with liver damage （ 10.0% ） ;32 patients had liver damage in the control group （34.8%） ;among 10 HBsAg positive patients ,there were 6 cases with liver damage（ 54.5% ）. There was significant difference between the two groups （P 〈 0.01 ）. The liver functions of HBsAg positive patients were more vulnerable to damage. Conclusions The clinical effect of the oxymatrine in preventing liver injury caused by antitubercular a- gents is specific, safe and effective.