慢性乙肝患者抗病毒治疗血清IL-10、IL-12、sIL-2R、TNF水平变化的临床观察

Effects of interferon treatment on the levels of IL-10,IL-12,sIL-2R,TNF in the serums in patients with the chronic hepatitis B

目的 探讨IL 10、IL 12、sIL 2R、TNF在慢性乙型肝炎发病中的作用 ,观察IFN抗病毒治疗对于上述因子水平的影响。方法 ELISA法检测 14例正常人及 30例慢性肝炎患者 (包括IFN治疗前后 )血清中上述细胞因子水平。结果 慢性肝炎患者血清中上述细胞因子水平显著高于正常对照组 (P <0 .0 5 ) ,且其值与ALT显著正相关 ;经IFN治疗后上述因子水平均明显降低 ,抗病毒无效组治疗前血清中sIL 2R、IL 10水平明显高于有效组 (P <0 .0 5 )。结论 上述因子共同参与了慢性乙型肝炎的发病 ,并可用于评价IFN对于机体免疫状态的影响 ;且sIL 2R、IL 10对预测抗病毒疗效有重要意义。

Objective To observe the effect on IL 10,IL 12,sIL 2R,TNF in the pathogenesis of chronic hepatitis B and to study the effects of interferon on the levels of cell factors mentioned above.Methods The levels of IL 10,IL 12,sIL 2R,TNF were detected by ELISA in the serums of 14 normal persons and 30 patients with chronic hepatitis B(including per and post treatment).Results The levels of IL 10,IL 12,sIL 2R,TNF of patients with chronic hepatitis B were significantly higher than those of normal control group,and these values were significantly positive correlation to ALT level;After interferon treatment,the levels of cell factors mentioned above were significantly decreased,and the levels of sIL 2R,IL 10 in ineffective group of antiviral treatment were significantly higher than those in effective group of antiviral treatment before treatment.Conclusion IL 10,IL 12,sIL 2R,TNF all participate in the attack of chronic hepatitis B;IL 10,IL 12,sIL 2R,TNF are the important markers of evaluating the regulating effect of interferon on immunity of organism,and sIL 2R,IL 10 are important to predict antiviral efficacy.