摘要
目的 探讨高胰岛素血症对原发性高血压(EH) 内皮细胞功能的影响,了解胰岛素(INS) 与EH 患者血浆内皮素(ET) 和一氧化氮(NO)水平的关系。方法 应用放免法和化学法检测82 位EH患者血浆INS、ET和NO水平,依据患者血浆INS水平将EH患者分为高INS血症(HI)组及非高INS血症(NHI)组,分析2 组间数据。结果 EH患者血浆INS、ET水平及ET/NO升高,NO水平下降。血浆NO水平及ET/NO比值与INS水平相关(r= 0.33和- 0.25,P<0.01 和0.05) 。亚组中,HI组INS、NO水平高于NHI组。血浆NO水平与INS中度相关(r=0.51,P< 0.01)。在NHI组,则关系不明显。结论 EH 患者内皮细胞功能障碍,ET/NO 比值失衡,高胰岛素血症对此产生了一定影响。仅在伴有高胰岛素血症的EH 患者,其血浆NO水平才与INS呈正相关。
Objective To investigate the influence of hyperinsulinemia(HI) on endothelial function in patients with essential hypertension (EH), and the relationship of the plasma level of insulin (INS) to those of endothelin(ET) and nitric oxide (NO). Methods 82 patients with EH were studied by measuring plasma levels of INS, ET and NO using radioimmunoassay and chemical methods. According to the level of plasma INS,the EH patients were divided into 2 subgroups: hyperinsulinemia group (HI) and non-hyperinsulinemia group (NHI). Results The levels of plasma INS and ET and the ratio of ET/NO were increased in EH patients, compared with the control (16.53±10.46 vs 9.39±2.52, 49.32±15.97 vs 39.37±8.39 , 6.36±4.43 vs 2.55± 0.60 , respectively P <0.01).The plasma level of NO was decreased in the patients (9.63± 3.49 vs 15.68±2.50, P <0.01), The plasma NO and ET/NO ratio were correlated to plasma INS (r=0.33 and -0.25, P<0.01 and 0.05 respectively).The levels of plasma INS and NO were higher in HI patients than in NHI patients (27.03±11.51 vs 11.06±3.61, P <0.01; 10.86±2.61 vs 8.92±3.81, P <0.05, respectively).The level of plasma NO was moderately correlated to plasma INS ( r =0.51, P <0.01) in HI patients, but no such correlation was in NHI patients. Conclusion Endothelial cell dysfunction and imbalance of ET/NO present in EH are influenced by HI to a degree. The level of plasma NO is positively correlative to plasma INS only in patients of EH with HI.
出处
《徐州医学院学报》
CAS
2000年第1期43-45,共3页
Acta Academiae Medicinae Xuzhou
关键词
原发性高血压
内皮细胞
高胰岛素血症
病理
essential hypertension
endothelial cells
insulin
endothelin
nitric oxide