神经妥乐平联合依托考昔治疗强直性脊柱炎疼痛的临床观察

Observation on the curative effect of neurotropin combined with etoricoxib in the treatment of pain in patients with ankylosing spondylitis

目的观察神经妥乐平对强直性脊柱炎（AS）所致疼痛的疗效。方法将30例AS患者在常规治疗的基础上，按数字表法随机分为观察组15例、对照组15例，男女比例均衡，对照组单独予神经妥乐平7．2Nu加0．9％氯化钠注射液250ml，静脉滴注2周；观察组静脉滴注神经妥乐平联合口服依托考昔片60mg，1次／d，应用2周。用AS疾病活动指数（BASDAI）、AS功能指数（BASFI）、脊柱痛视觉模拟（VAS）评分、夜间痛VAS评分及晨僵时间来评定两组疼痛缓解情况，并进行统计分析。结果观察组疼痛强度改善优于对照组，差异有统计学意义（P〈0．05），无严重不良反应。结论神经妥乐平联合依托考昔治疗强直性脊柱炎疼痛疗效显著，安全性好。

Objective To discuss the curative effect of neurotropin combined with etoricoxib in the treatment of pain in patients with ankylosing spondylitis （AS）. Methods 30 AS patients were randomly divided into two groups. The control group was treated with 7.2Nu neurotropin injection for two weeks. The observation group was given neurotropin injection and 60rag etoricoxib tablets oral per day for two weeks. The Bath AS activity index（ BASDAI）, Bath AS functional index （BASFI） , rachiodynia, hypnalgia and morning stiffness were observed. Results The total effective rate of observation group was superior to the control group, the difference was significant （ P 〈 0.05 ）. No severe adverse reaction was observed. Conclusion Neurotropin combined with etoricoxib has definite effect on AS.