胃癌淋巴结微转移的临床意义

The clinical significance of lymph node micrometastasis in patients with gastric cancer

目的 探讨淋巴结微转移与胃癌生物学行为及预后的关系。方法 采用免疫组织化学方法 ,用细胞角蛋白单抗MNF 116检测淋巴结微转移。结果 6 0例患者淋巴结微转移的阳性率为 5 8 3% ,微转移与肿瘤浸润深度及淋巴管侵犯密切相关 (P <0 0 5 )。临床病理分期Ⅱ、Ⅲ期患者微转移的阳性率明显高于Ⅰ期 (P <0 0 5 )。在Ⅰ期 ,阳性组的 5年生存率明显低于阴性组 (P <0 0 5 )。多变量分析表明淋巴结微转移是独立的预后因素。结论 淋巴结微转移对胃癌预后起着重要作用。

Objective To evaluate the relationship between lymph node micrometastasis and biological behavior and prognosis of gastric cancer.[WT5”HZ] Methods[WT5”BZ] Immunohistochemical method was used to detect the micrometastasis of lymph nodes from 60 cases of gastric cancer.[WT5”HZ] Results[WT5”BZ] Micrometastases were found in 96 lymph nodes (3 1%) of 35 cases (58 3%). The presence of micrometastasis was significantly correlated with the depth of invasion and lymphatic invasion ( P <0 05). Micrometastases were more frequently found at stage Ⅱ and Ⅲ than those at stage Ⅰ( P =0 005).Carcinomas with micrometastasis had a poorer prognosis than those without at stage Ⅰ ( P <0 05). Multivariate analysis indicated that micrometastasis was an independent prognostic factor.[WT5”HZ] Conclusions[WT5”BZ] Lymph node micrometastases play an important role in the prognosis of gastric cancer.