PCNA表达与乳腺癌淋巴结转移及预后关系的探讨

Relationship of PCNA expression to lymphnode metastasis and prognosis in breast carcinoma

目的 探讨增殖细胞核抗原PCNA表达与乳腺癌淋巴结转移及预后的关系。方法 用免疫组化法对 80例乳腺癌伴淋巴结转移和无转移组做PCNA检测 ,并与随访资料进行比较分析。结果 PCNA阳性率在乳腺癌伴淋巴结转移组 6 8.18% ,无转移组 31.82 % ,两组间存在显著性差异 (P <0 .0 0 5 )。随着组织学分级的增高 ,PCNA的表达呈递增趋势 ,Ⅰ级与Ⅱ、Ⅲ级间阳性率差异存在显著性 (P <0 .0 1)。 5年生存率 (30 .5 1%与 6 6 .6 6 % )也存在显著差异 (P<0 .0 0 5 )。结论 PCNA表达与乳腺癌淋巴结转移及预后密切相关 ,是乳腺癌患者预后判定有价值的生物学指标。

Objectives To study the relationship between the expression of PCNA and the lymphnode metastasis and prognosis of breast cancer.Methods eighty of breast cancer with or without lymphnode metastasis were studied for the expression of PCNA in the tumor′s tissue section by using LSAB method.The result were analysised to the follow up material in this group of patients.Result The positivity rate of PCNA expression in node-positive and in node-negative groups were 80% and 33% respectively(P<0.05) with the increase of histological grade the positivity rate of PCNA expression increased (P<0.05).the node-positive and in node-negative groups were significant difference in 5 years survival rate (31% and 65%)(P<0.005).Conclusions The expression of PCNA in closely linked to lymphnode metastasis and prognosis of breast carcinoma,and should be considered to a certain extent as an index of malignant degree and prognosis.