未成熟脑惊厥性损伤与SNR关系

Immature brain conyulsion sex damage and SNR relationship

惊厥是儿科常见的急重症,发生率高达4%,反复的惊厥性损伤不但影响患儿的智力发育,而且严重惊厥可引起永久性脑损伤,留有后遗症,给患儿家庭带来沉重打击。大量研究证明,黑质网状部(substantia nigra pars reticulate SNR)在癫痫发作中起着"闸门"和"屏蔽"的作用,而未成熟脑耐受惊厥性损伤的机制与SNR特异性屏蔽的神经保护作用有关。

Convulsion in pediatric emergency medicine is common, the incidence was 4%, repeated seizure -induced injury not only affects children＇s intellectual development, but also serious convulsion can cause permanent brain damage, stay have sequela, dealt a heavy blow to the families with children. Numerous studies demonstrate that, the substantia nigra pars reticulata （ substantianigra pars reticulate SNR） plays a ＂gate＂ and ＂shield＂ role in the seizure, and the neuroprotective effect of shielding mechanism and the specificity of SNR in immature brain injury is related to the tolerance of convulsion.