孕妇血8-iso-F2α、胱抑素C及CRP在妊娠高血压疾病诊断中的意义

Significance of serum 8 - iso - prostaglandin F2α,cystatin C and C - reactive protein detection for the diagnosis of pregnancy induced hypertension

目的研究妊娠高血压疾病孕妇血清8-iso-F2α、胱抑素C及CRP水平的变化与妊娠高血压疾病发生、发展的关系。方法选择妊娠高血压疾病患者56例及正常孕妇女56例检测其血清8-iso-F2α、胱抑素C及CRP水平。结果妊娠高血压疾病组血清8-iso-F2α、胱抑素C及CRP水平明显升高,与对照组相比,有显著差异(P<0.01);重度妊娠高血压疾病患者则明显高于中度和轻度妊娠高血压疾病患者组,差异有统计学意义(P<0.01)。结论动态监测血清中8-iso-F2α、胱抑素C、CRP水平有利于妊娠高血压疾病的预防及早期治疗,可以评价本病的病情发展及预后。

Objective ： To investigate the Changes of 8 - iso - prostaglandin F2α, cystatin C and c - reactive protein in the pathogenesis of pregnancy induced hypertension （PIH） and study the relationship with the pregnancy induced hypertension. Methods： Choose pregnancy induced hypertension patients 56 cases （ the observation group） and the same period normal late pregnant women 56 cases （the control group） and compared with the serum levels of 8 -iso -prostaglandin F2α, cystatin C and c -reactive protein of the observation group and the Control group. Results ： The serum levels of 8 - iso - prostaglandin F2α, cystatin C and c - reactive protein in the the observation group increased significantly than the control group. Severe disease patients with hypertension is obviously higher than moderate and mild pregnancy induced hypertension patients group. Conclusions ： Dynamic monitoring the serum level of 8 - iso - prostaglandin F2α, cystatin C and c - reactive protein will be helpful to evaluate the development of and prognosis of PIH and early diagnosis and remedy of PIH.