比较黄体酮阴道缓释凝胶与黄体酮联合地屈孕酮对体外受精的黄体支持

To comparethe function of vaginal progesterone gel and Progesterone combining with dydrogesterone for luteal support after in vitro fertilization /intracytoplasmic sperm injection

目的探讨黄体酮阴道缓释凝胶与黄体酮联合地屈孕酮两种黄体支持方法对IVF-ET/ICSI术后不孕患者的妊娠结局影响。方法对200例进行IVF-ET/ICSI术的不孕患者进行回顾性分析,按取卵后不同的黄体支持方法分为两组,A组采用黄体酮阴道缓释凝胶进行黄体支持;B组采用黄体酮联合地屈孕酮进行黄体支持;结果 A、B组两组所获得的临床妊娠率、异位妊娠率、多胎妊娠率及早期流产率均无显著性差异(P>0.05),阴道黄体酮凝胶组不良反应较轻,两组妊娠患者早期出血率无明显差异(P>0.05)。结论采用黄体酮阴道缓释凝胶对行IVF-ET/ICSI术的不孕患者进行黄体支持与黄体酮联合地屈孕酮进行黄体支持所获得的妊娠结局是一致的,且其使用更方便,患者耐受性更好,在临床上可以单独应用黄体酮阴道缓释凝胶进行IVF-ET/ICSI术后的黄体支持。

Objective ： To study the effect of vaginal progesterone gel and Progesterone combine with dydrogesterone for luteal support after in vitro fertilization/intracytoplasmic sperm. Methods： The data of 200 patients undergoing IVF - ET/ICSI after oocytes retrieved were retrospectively analyzed. The patients were divided into Group A （simple vaginal progesterone gel） with 100 cases, Group B （Progesterone combine with dydrogesterone） 100 cases according different supporting methods for the corepus luteum. Resuits： There were no significant differences in clinic pregnancy rate, the eetopic pregnancy rate, multiple pregnancy rate and the early abortion rate among two groups （ P 〉 0. 05 ）. Adverse reaction is slighter in group A than in group B, There were no significant differences in the early bleeding rate among two groups （ P 〉 0. 05 ）. Conclusion ： Two projects had the same pregnancy outcome as the resuits of the patients undergoing IVF - ET, But vaginal progesterone gel are more convenient and easy to use, so it can be use for luteal support after IVF - ET/ICSI, alone.