超促排卵过程中穿刺小卵泡治疗顽固性多囊卵巢综合征的临床应用

The process of promoting the ovulation small follicular puncture resistant polycystic ovarian syndrome treatment of clinical application

目的探讨超促排卵过程中小卵泡穿刺术对治疗顽固性多囊卵巢综合征(PCOS)患者的临床应用。方法选取对克罗米芬(CC)及尿促性腺激素促排卵抵抗的顽固性PCOS不育患者共42例44周期,采用体外受精-胚胎移植(IVF-ET)技术助孕,随机分为2组,超促排卵过程中,因卵泡发育慢卵泡多,雌二醇(E2)增高,采用小卵泡穿刺术并继续治疗周期,与未穿刺周期比较在平均促性腺激素(Gn)使用天数、Gn用量、OHSS发生率、周期取消率、受精率及妊娠率等方面进行比较。结果穿刺组OHSS发生率、周期取消率、受精率及妊娠率等均较未穿刺组明显改善(P<0.05)但平均Gn天数及Gn量增加(P<0.05)。结论对顽固性PCOS患者采用IVF助孕,促排卵过程中采用小卵泡穿刺治疗是一种安全的、成功率比较可靠的治疗方法,但可能使患者治疗费用增加。

Purpose ： Discusses the promoting the process of small and medium - sized follicle ovulation percutaneous treatment resistant polycystic ovarian syndrome （PCOS） patients for clinical application. Methods： Select club to g Finn （CC） and urine gonadotropins promote ovulation resistance of infertility patients with intractable PCOS 42 patients with 44 cycle, using in vitro fertihsatian and embryo transplantation （IVF -ET） technology to help pregnant, randomly divided into two groups, the process of promoting the ovulation, for follicular slow follicle, estradiol （E2） increased, the small follicular technic and continue to treatment cycle, and not puncture cycle comparison in average gonadotropins （Gn） days, Gn dosage, use OHSS incidence, cycle cancellation rate, fertility rate and pregnancy rate by comparison. Results： Puncture group OHSS incidence, cycle cancellation rate, fertility rate and pregnancy rates are less obviously improve the puncture group （P 〈 0.05） but average Gn days and Gn increased （P 〈 0. 05）. Conclusion： In treating patients with PCOS by IVF help pregnant, and in the process of ovulation using small follicular puncture therapy is a safe and effective treatment method is reliable, but may make patients treatment costs increase.