蛋白质图案构筑及其应用研究进展

Fabrication and applications of the protein patterns

蛋白质作为生物体内一类重要的大分子已被广泛地应用于构筑图案化结构,所得到的蛋白质图案在医疗诊断、组织工程、生物传感和药物筛选等领域均表现出了巨大的应用价值.目前,蛋白质图案的构筑方法主要有两种:(1)在利用微加工技术制备的微结构上进行蛋白质的后续接枝实现蛋白质图案的构筑;(2)直接用蛋白质分子构筑图案化结构.本文对当前常用的蛋白质图案构筑技术进行了综述,并对蛋白质图案的实际应用进行了总结,最后对蛋白质图案构筑技术的发展方向以及蛋白质图案的应用前景进行了展望.

Protein has been widely used for fabricating patterned structures since it is one of the most important macromolecules in living organisms, and protein patterns possess potential applications in many fields such as medical diagnosis, tissue engineering, biosensor, and medical screening. At present, there are two fashions to fabricate protein patterns： （1） grafting the protein to the microstructure which is prepared by microfabrication techniques; the other one is achieving the patterned protein structures directly. Here we provide an overview on current status of the fabrication techniques and the applications of the protein patterns, and then we give an outlook on the development of the fabrication techniques and the prospective applications of the protein patterns in future research.