益生菌调节肠道上皮屏障功能及作用机制

Functions of Intestinal Epithelial Barriers Modulated by Probiotics and Mechanisms

动物肠道是一个具有生物多样性的微环境,单层的上皮细胞将共生微生物和病原菌与下层的免疫细胞分割构成肠道屏障。益生菌是一类对宿主有益的微生物,益生菌与肠道上皮细胞、下层免疫细胞共同构成了3个屏障,分别是机械屏障、化学屏障和免疫屏障。本文主要综述肠道上皮屏障及微生态系统组成、益生菌增强肠道上皮屏障功能作用以及微生物与肠道上皮之间的相互作用以及机制。

The intestinal tract of animal involves a diversity of microbial environment. Intestinal epithelial cells separate commensal microorganisms and pathogens from the underlying immune cells to be part of the intestinal epithelial barriers. Probiotics are a certain kind of microorganisms that have beneficial effects on the host, and play a part with intestinal epithelial cells and immune cells in constituting three functional barriers which are mechanical barrier, chemical barrier and immune barrier. This article reviewed the intestinal epithelial barrier and micro ecosystem composition, the functions of probiotics in enhancing intestinal epithelial barriers, as well as mechanisms and the interaction between microbe and intestinal epithelium.