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阿托伐他汀在冠心病治疗中IL-6、APN水平动态变化观察 被引量：6

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摘要 目的观察阿托伐他汀在治疗冠状动脉粥样硬化性心脏病(冠心病)过程中的白细胞介素6(interlerkin-6,IL-6)及脂联素(adiponectin,APN)水平动态变化过程。方法选择冠心病患者160例,随机分为对照组和治疗组各80例,2组均按冠心病伴高脂血症常规内科治疗,疗程8周。治疗组加用阿托伐他汀20mg口服,1次/d。分别于治疗前及治疗4周、8周时采集患者肘静脉血,ELISA法检测后比较2组IL-6及APN水平动态变化。结果与治疗前比较,2组治疗后IL-6水平均减低,APN水平均升高,且治疗组尤其明显,差异有统计学意义(P<0.05)。结论应用阿托伐他汀治疗冠心病能显著降低患者IL-6水平、升高APN水平。
作者 高海燕 崔岭 韦洪艳 刘英权 闫文杰
机构地区 河北省石家庄市第一医院干部保健处 河北省石家庄市第一医院肾内科 河北省石家庄市第一医院麻醉科 河北省石家庄市第一医院皮肤科 河北省平山县医院心内科
出处 《河北医科大学学报》 CAS 2013年第9期1051-1053,共3页 Journal of Hebei Medical University
基金 石家庄市科技支撑计划项目(12146543)
关键词 冠状动脉疾病 阿托伐他汀 白细胞介素6 脂联素
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

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共引文献7

同被引文献58

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引证文献6

二级引证文献33

河北医科大学学报
2013年 第9期

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