白血病合并血栓栓塞尸检12例临床病理分析

Analysis on clinical and pathological features of 12 cases of leukemia complicated with thrombosis via autopsy

目的探讨白血病合并血栓栓塞的临床病理特征。方法对我院1956—1988年剖检的12例合并血栓栓塞的白血病患者临床及病理资料回顾性分析。结果 (1)急性髓细胞白血病7例,急性淋巴细胞白血病3例,慢粒急髓变1例,慢粒急淋变1例;初治患者9例,复发患者3例。(2)6例患者合并霉菌性败血症,4例为毛霉菌,2例为曲霉菌。(3)WBC(96.4±12)×109/L,PLT(73.2±12)×109/L。(4)急性淋巴细胞白血病患者在化疗中均应用门冬酰胺酶。结论白血病合并血栓栓塞并不少见,临床应引起重视。

Objective To study the clinical and pathological features of leukemia complicated with thrombosis. Methods The clinical and pathological features of 12 cases of leukemia complicated with thrombosis were retrospectively analyzed by means of au- topsy from the year of 1956 through 1988. Results （ 1 ） Acute myeloid leukemia accounted for 7 cases, acute lymphoid leukemia for 3 cases, the conversion into acute myeloid leukemia from chronic myelocytic leukemia for 1 case, the conversion into acute lymphoid leukemia from chronic myelocytic leukemia for 1 case, newly diagnosed leukemia 9 cases, and recurrent leukemia for 3 cases. （2） Accompanied by mycotic septicemia accounted for 6 cases, including 4 cases of mold fungi and 2 cases of aspergilli. （3） The mean white blood cell counting was （96.4 ± 12） ×109/L, and platelet counting was （73.2 ± 12）× 109/L. （4） Aspara- ginase was applied to all the cases of acute lymphoid leukemia. Conclusion Leukemia complicated with thrombosis, which is not uncommon, should be paid more attention to.