肺结核耐药情况和影响因素分析

Tuberculosis Patients with Drug-Resistant and Impact Factors

目的:对肺结核耐药影响因素进行研究和分析,旨在为肺结核治疗提供可靠依据。方法:采集我院肺结核患者痰标本,并采用改良酸性罗氏培养基进行菌株培养,经TCH、PNB鉴别分型,确定137株作为药敏研究对象,对临床较常用的8种抗结核药物耐药性情况进行检测和分析。结果:137株中有108例为人结核分枝杆菌,有27例为牛结核分支杆菌,2例为非结核分枝杆菌。单一耐药情况为:初治组耐药情况为异烟肼(H)9.83%>链霉素(S)6.56%>乙胺丁醇(E)1.64%;复治组耐药情况为异烟肼(H)10.39%>利福平(R)、链霉素(S)2.6%>乙胺丁醇(E)、氧氟沙星(Ofx)1.30%,组合耐药初治与复治药物耐药具有显著差异(P<0.05)。结论:肺结核致病菌以人结核杆菌为主,临床8种常见抗结核药物均有一定耐药性,以是异烟脐、链霉素表现最为明显,初治与复治为组合耐药性的关键影响因素。

Objective：Factors impact resistant tuberculosis research and analysis designed to provide a reliable basis for tuberculosis treatment.Methods： 137： Acquisition of tuberculosis patients sputum specimens in our hospital,and modified acid carried Roche medium,strains were cultured,TCH,PNB identify genotyping to determine drug sensitivity study,the clinical 8 anti-TB drug resistance detection and analysis.Results： 137 of the 108 cases of human M.tuberculosis,27 cases of Mycobacterium tuberculosis for cattle,two cases of nontuberculous mycobacteria.A single drug： the naive group drug resistance to isoniazid（H） 9.83%＆gt; streptomycin（S） 6.56%＆gt; ethambutol（E） 1.64%;retreatment group resistant to isonicotinic hydrazine（H） 10.39%＆gt; rifampicin（R）,streptomycin（S） 2.6%＆gt; ethambutol（E）,ofloxacin（Ofx） 1.30%,the combination drug initial treatment and retreatment drugs resistance with a significant difference（P＆lt;0.05）.Conclusions： The tuberculosis pathogens People Mycobacterium tuberculosis based,there is a certain resistance to common anti-TB drugs in clinical,so isonicotinoyl umbilical,streptomycin was the most obvious,initial treatment and retreatment of a combination of resistance the key factors.