尿毒清颗粒配合依那普利延缓慢性肾功能衰竭的临床疗效研究

Urine Poisonous Clear Particles Enalaprilat Delay Chronic Renal Failure with the Clinical Curative Effect of the Research

目的:研究尿毒清颗粒与依那普利相配合对慢性肾功能衰竭(CRF)延缓的临床疗效。方法:86例CRF住院患者随机分成两组,即治疗组44例,对照组42例,对照组患者给予依那普利与低蛋白饮食,其含量分别为6mg,qd与0.5g/(kg.d),而治疗组是在对照组的治疗方法前提下,又加用了尿毒清颗粒,其使用量为每天3次,每次5g,两组疗程都是两年,对两组患者临床治疗前后的尿量、血压、尿素氮、血生化、血肌酐与24h的尿蛋白定量变化进行研究。结果:两组患者临床治疗之后,其血肌酐与尿素氮均显著降低,P<0.01或者P<0.05,并且治疗组比对照组的下降幅度更为显著P<0.01,对照组有效率为76.19%,治疗组有效率为93.18%,治疗组有效率比对照组要明显高,其差异性显著P<0.05。结论:尿毒清颗粒与依那普利相配合,对CRF延缓,临床疗效满意且安全性好。

Objective： To study the urine poisonous clear particles and enalaprilat phase fit for chronic renal failure delay clinical curative effect.Methods： 86 cases of chronic renal failure hospitalized patients were randomly divided into two groups,namely the treatment group 44 cases and control 42 cases,control group patients give enalaprilat and low protein diet,the content of 6 mg respectively,qd and 0.5 g/kg.d）,and the treatment group is in the control group therapy premise,with the added urine poisonous clear grain,its usage every day for three times,each time 5 g,two groups of treatment are two years,the two groups of patients before and after the clinical treatment of urine,blood pressure,urea nitrogen,serum creatinine and blood biochemistry,24 h urine protein quantitative change research.Results： Two groups of patients after clinical treatment,the serum creatinine and urea nitrogen were significantly lower,P＆lt; 0.01 or P＆lt; 0.05,and the treatment group than in the control group decline was more significant（P＆lt; 0.01）,and the control group,the effective rate was 76.19% in the treatment group,the effective rate was 93.18% in the treatment group than the control group significantly high efficient,the significant differences P＆lt; 0.05.Conclusion： Urinary poisonous clear particles and enalaprilat suitably,for chronic renal function failure delay,clinical curative effect satisfaction and good safety.