2010～2011年酵母样真菌耐药分析

Yeast-like Fungi Resistant Analysis between 2010～2011

目的:阶段性总结和分析真菌分布情况及耐药性,以提高临床的治疗与预防效果,为我国医疗感染用药以及疾病治疗预防提供指导意见。方法:取我院患者送检的分泌物、尿液、粪便、咽拭子等的化验结果及药敏报告,经真菌培养鉴定,共检出酵母样真菌150例,药敏试验检测真菌的耐药性。结果:酵母样真菌分布按百分率由高到底排序为:白色念珠菌(65.33%)、光滑念珠菌(14.67%)、热带念珠菌(12%)、克柔念珠菌(5.33%)和近平滑念珠菌(2.67%)。按敏感率排序:两性霉素B(92%)、伏立康唑(75.33%)、氟胞嘧啶(64.67%)、益康唑(58%)、氟康唑(58%)、酮康唑(57.33%)、咪康唑(41.33%)、伊曲康唑(18%);按耐药率排序:两性霉素B(5.33%)、伏立康唑(7.33%)、氟康唑(15.33%)、氟胞嘧啶(29.33%)、咪康唑(32%)、益康唑(32.67%)、酮康唑(33.33%)、伊曲康唑(74.67%)。结论:白色念珠菌是酵母样真菌感染的主要菌种,两性霉素B可作为临床用药的首选,伏立康唑次之,抗菌素用药还应谨慎,勿滥用。

Objective：Phase summary and analysis of fungal distribution and drug resistance,to improve the treatment and prevention of clinical effect,and to provide guidance for our medical infection medication,and treatment of disease prevention.Methods：Secretions,ur ine,feces,throat swab test results and susceptibility reports of censorship in patients in our hospital.Fungal culture identified 150 cases were detected in the yeast-like fungi,susceptibility test for detection of fungal resistance.Results： Yeast-like fungi distribution by percentage high in the end sort：Candida glabrata,Candida albicans（65.33%）、Smooth candida（14.67%）,Candida tropicalis（12%）,krusei candidiasis（5.33%） and Candida parapsilosis（2.67%）.Sort by sensitive rate：amphotericin B（92%）,voriconazole（75.33%） of flucytosine（64.67%）,econazole（58%）,fluconazole（58%）,ketoconazole（57.33%）,the miconazole（41.33%）,Iraq Qu itraconazole（18%）;Sort by resistance rates：Amphotericin B（5.33%）,voriconazole（7.33%）,fluconazole（15.33%） of flucytosine（29.33%）,miconazole（32%）,econazole（32.67%）,ketoconazole（33.33%）,the Iraqi song itraconazole（74.67%）.Conclusion：Candida albicans is the main strains of yeast-like fungal infections,amphotericin B as the first choice of clinical medicine,voriconazole followed,antibiotic medication should also be noted that caution,do not abuse.