急性肺栓塞患者血浆脑钠肽与右心功能的关系及其预后评估价值被引量：2

BNP levels in patients with acute pulmonary embolism are correlated with right ventricular function

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摘要目的研究血浆脑钠肽（BNP）与急性肺栓塞（APE）患者右心室功能不全（RVD）的关系及其预后评估价值。方法采用酶联免疫法测定44例APE患者血浆BNP水平，同时根据超声心动图检查分为RVD组和无RVD组。观察两组间血浆BNP水平差异及血浆BNP水平与不良事件发生率的关系。结果 APE患者RVD组BNP水平[（2352.5±1987.8）pg/ml]高于无RVD组[（349.9±299.4）pg/ml]（P＜0.01）；低BNP者不良事件发生率（10.0％）低于高BNP者（69.2％），差异有统计学意义（P＜0.05）；低BNP者1年生存率高于高BNP者（χ2=6.554,P＜0.05）。结论 BNP可作为反应APE患者RVD的有效手段，对预测患者不良事件及预后有重要作用。 Objective To investigate the correlation of plasma B type natriuretic peptide （BNP） level with right ventricular function in patients with acute pulmonary embolism. Methods Plasma BNP level was measured by ELISA in 44 patients with a-cute pulmonary embolism. According to the results of echocardiography,the patients were classified as normal right ventricular function group and right ventricular dysfunction group.The correlation of plasma BNP level with ventricular function and the inci-dence of adverse events was analyzed. Results BNP level in right ventricular dysfunction group were significantly higher than that in normal right ventricular function group （2 352.5±1 987.8 vs 349.9±299.4 pg/ml, P〈0.01）.The incidence of adverse out-come events in the BNP- positive group was higher than that in BNP- negative group （69.2%vs 10.0%, P〈0.05）.The survival rate in the BNP- negative group was higher than that in BNP- positive group （χ2=6.554, P〈0.05）. Conclusion Plasma BNP lev-els are correlated with right ventricular function in patients with acute pulmonary embolism, which may be of prognostic value for acute pulmonary embolism.

作者周忠良季巧英马旭金凯频

机构地区东阳市人民医院血管外科

出处《浙江医学》 CAS 2013年第15期1432-1434,共3页 Zhejiang Medical Journal

关键词脑钠肽急性肺栓塞右心功能 Brain natriuretic peptide Acute pulmonary embolism Right ventricular function

分类号 R563.5 [医药卫生—呼吸系统]

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