摘要
[目的]研究巨噬细胞抑制因子-1(MIC-1)血清水平在早期肺癌诊断中的应用价值。[方法]采用双抗体夹心ELISA监测182例早期肺癌患者、36例肺良性疾病患者及129例正常对照人群血清MIC-1浓度,采用电化学发光免疫分析仪及化学发光免疫分析仪分别检测肺癌患者血清CEA、CA125、NSE、Cyfer21-1和SCC浓度。[结果]肺癌组患者血清中MIC-1水平显著性高于正常对照组(P<0.001)和肺良性疾病组(P=0.002)。根据ROC曲线和正常人群的MIC-1血清水平,设1000pg/ml为诊断肺癌的临界值,MIC-1检测肺癌的敏感度和特异性分别为68.1%和96.8%。MIC-1诊断Ⅰ～Ⅱ期肺癌的敏感度优于肿瘤标志物CEA、CA125、NSE、SCC和Cyfer21-1,敏感度分别为68.1%、15.9%、10.4%、3.3%、22.1%和23.8%。[结论]MIC-1在早期肺癌诊断中有临床应用价值,可能成为比较理想的肺癌诊断及筛查标志物。
[Purpose] To investigate the clinical value of serum macrophages inhibitory cytokine-1（MIC-1） in patients with early stage lung cancers.[Methods] The double antibody sandwich ELISA was used to detect serum MIC-1 level in 182 patients with early stage lung cancer,36 patients with benign pulmonary disease and 129 healthy persons.ELCIA and CLIA were used to detect the serum CEA,CA125,NSE,Cyfer21-1 and SCC level.[Results] MIC-1 level in lung cancer group was significantly higher than that in normal control group（P0.001）and in benign disease group（P=0.002）.According to ROC curve and MIC-1 level of normal control group,the cut-off value of MIC-1 was set at 1 000pg/ml,the specificity and sensitivity were 96.8% and 68.1% respectively.The sensitivity of MIC-1 for early stage lung cancer was higher than that of CEA,CA125,NSE,SCC and Cyfer21-1 respectively with sensitivity of 68.1% 、15.9% 、10.4% 、3.3% 、 22.1% and 23.8% respectively.[Conclusions] MIC-1 has a clinical value for diagnosis in early stage lung cancer.MIC-1 might be a new serum marker for lung cancer.
出处
《中国肿瘤》
CAS
2013年第9期753-756,共4页
China Cancer
基金
国家高技术研究发展863计划资助项目(2008AA02Z415)
北京希望马拉松专项基金临床课题(LC2012A12)
中央级公益性科研院所基本科研业务费资助项目(JK2011B05)
关键词
巨噬细胞抑制因子-1
肿瘤标志物
肺癌
macrophages inhibitory cytokine-1（MIC-1）
tumor marker
lung cancer
