摘要
Toll样受体(TLR)是天然免疫中重要的模式识别受体,主要在免疫细胞上表达,能特异性地识别病原相关分子模式,并在启动和调节天然免疫及获得性免疫中起到重要作用。研究表明TLR4在炎性肠病和结肠癌中表达增高。文章主要综述TLR4在结肠癌及炎性肠病癌变过程中的作用。
Toll-like receptors （ TLRs ） are the important pattern recognition receptors （PRR） in innate immunily,located on the cell surfaee,and can identify the pathogen associated molecular patterns （PAMPs）specificity. TLRs play an important role in in the initiation and regulalion of innate immunity and acquired immunity. Studies sug- gest that TLR4 expression increase in inflammatory, bowel disease （IBD） and coloreclal cancer. The role of TLR4 in colon cancer and earcinogenesis of IBD are reviewed.
出处
《肿瘤学杂志》
CAS
2013年第9期735-738,共4页
Journal of Chinese Oncology
关键词
TOLL样受体4
炎性肠病
结肠肿瘤
Toll-like receptor 4
inflammatory bowel disease
colorectal neoplasms
