家兔椎动脉型颈椎病模型制作的实验研究——经颅多谱勒检测

AN EXPERIMENTAL STUDY OF MODELS OF VERTEBROARTERIAL SPONDYLOPATHY IN RABBITS——A TCD Examination

目的 :研究单侧颈椎肌肉纤维化孪缩、单侧椎动脉 (VA)纤维化阻滞后 ,基底动脉 (BA)、左右侧VA(LVA、RVA)血液变化和丹参注射液胃肠灌注后的恢复过程。方法 :选取家兔58只 ,将775注射液注射至左侧3～5颈椎横突侧面 ,分别于造模前、后2 ,4,6,8周以颈多谱勒 (TCD)测定双侧VA、BA血流平均速度 (Vm)、博动指数 (Pi)、阻力指数 (Ri) ;于造模后第6周随机选择6只动物 ,以丹参注射液灌胃2周 ,再次测定TCD。结果 :造模后BA和双侧VA的Vm递减 (P<0.01) ,使用丹参后BA的Vm恢复至造模前水平 (P<0.05) ;造模后LVA的Pi、Ri和BA的Ri递增 (P<0.01) ,使用丹参后未见恢复 (P<0.01) ,与造模8周未见使用丹参比较有明显改善 (P<0.01或0.05)。结论

Objective: To study the mechanism of vertebral basilar artery ischemia by means of TCD. Method: 775 injectio was given at the laterals of the 3～5 vertebral transverse processes. Vertebral mean ((Vm), pulse index (Pi) and resistance index (Ri) in the bilateral vertebral and basilar arteries was tested respectively 2, 4, 6 and 8 weeks before and after the models were made. 6 weeks after modeling, 6 rabbits were selected for gastric perfusion with red sage injectio and all indexes were tested by way of TCD. Results: Vm decreased steadily in BA and bilateral VA after modeling and recovered after administration of red sage injectio. Pi and Ri in the left VA and Ri in the BA increased steadily and did not recover after administration of red sage injectio. They improved greatly as compared with those at the end of the 8th week after modeling. Conclusion: Gastric perfusion with red sage injectio is obviously effective for VBI in animal models.