支气管哮喘患者治疗前后3项免疫指标的变化——T淋巴细胞亚群、红细胞免疫功能、血清免疫球蛋白水平的初步观察

CHANGES IN 3 IMMUNOLOGICAL INDEXES BEFORE AND AFTERTHE TREATMENT OF PATIENTS WITH BRONCHIAL ASTHMA

目的 :观察支气管哮喘患者T淋巴细胞亚群、红细胞免疫功能、血清免疫球蛋白水平的变化。方法 :测定22例急性发作期患者治疗前后3项免疫指标 ,并与25例正常人对照。结果 :支气管哮喘患者在急性发作期CD4及CD4/CD8、血清IgM水平明显增高 ,CD8、C3bRR则明显降低 ;在缓解期均有不同程度的恢复 ,而ICR无明显变化。结论 :支气管哮喘存在T淋巴细胞、红细胞免疫功能障碍及血清免疫球蛋白IgM水平增高 。

Objective: To study the changes in the subgroups of T-lymphocytes, immune functions of erythrocytes and serum levels of immunoglobulin in patients with bronchial asthma. Method: 22 cases were studied and their 3 immunological indexes both before and after the treatment were compared with those in 25 normal persons as the control. Results: In the acute stage, CD4, CD4/CD8 and serum IgM were significantly increased while CD8 and C3bRR remarkably decreased. Both restored to a certain degree during the remission stage. But ICR showed no obvious changes. Conlusion: Immunological malfunctions of T-lymphocytes and erythrocytes and the increased level of serum IgM may have played a role in the pathogenic mechanism of bronchial asthma.