神经心源性晕厥患者血浆儿茶酚胺及红细胞膜β-受体的变化

The changes of catecholamine and β-receptor of red blood cell membrane in the patients with neurocardiogenic mediated syncope

目的 :研究儿茶酚胺、β-受体在神经心源性晕厥 ( NMS)发生机制中的作用。方法 :用荧光法和受体的放射配基结合法分别测定 NMS( 2 4例 )组及正常对照组 ( 2 0例 )β-受体的密度和亲和力以及倾斜试验 ( HU T)过程中血浆儿茶酚胺浓度的变化。结果 :NMS患者 HU T倾斜 80° 3m in及晕厥发作时血浆中儿茶酚胺浓度明显高于倾斜前平卧位 ( P <0 .0 5～ 0 .0 1) ,亦明显高于对照组 ( P <0 .0 1)。NMS患者红细胞膜上 β-受体无论密度或亲和力与对照组相比均无明显差异。结论 :儿茶酚胺浓度的过度增高可能在 NMS发病过程中起重要作用 。

Objective:To study the effects of catecholamine and β receptor of redblood cell membrane in the pathogenesis of neurocardiogenic mediated syncope (NMS).Method:High speedion exchange column chromatography was used to measure the changes of plasma catecholamine concentration during head up tilt test;receptor radioligand binding assay was used to measure the number and affinity of β adrenoceptors between patients with NMS (n=24) and normal control subjects (n=20).Result:The plasma catecholamine concentrations were higher during in patients with NMS than that in control subjects (P< 0.05 ～ 0.01 ).No significant differences in the number and affinity of β receptor were seen between two groups.Conclusion:It suggests that significant increase of catecholamine concentration may play an important role in the pathogenesis of NMS.The number and affinity of β receptor have not difference between patients with NMS and normal control subjects.