摘要
目的观察妊娠高血压疾病(HDCP)患者治疗前后血清白介素(IL)-6、8、10水平变化。方法 50例HDCP患者(观察组)予以解痉、镇静、控制血压和利尿等对症治疗1周。观察治疗前后血清IL-6、8、10水平变化。选择同期正常妊娠晚期孕妇30例作为健康组。结果观察组患者治疗前血清IL-6、8水平明显高于健康组,IL-10水平明显低于健康组(P<0.01)。治疗1周后,观察组患者血清IL-6、8水平较前明显下降,IL-10水平较前明显上升(P<0.05)。结论 HDCP患者存在炎症细胞因子水平紊乱,体内存在局部炎症反应。血清IL-6、8、10水平改变反映了HDCP病情程度,可作为治疗疗效评估的指标。
Objective To observe the changes of serum interleukin-6, 8, and 10 of hypertensive disorder complicating pregnancy （HDCP） patients before and after medical treatment. Methods Fifty cases of HDCP patients were selected as observed group, who were given regular medical treatment of relieving spasm, tranquilizing mind, controlling blood pressure and promoting diereses for 1 week. the changes of serum interleukin-6, 8, and 10 of patients in observed group before and after medical treatment and clinical effect were observed. 30 cases of normal women in late pregnancy were selected as health group. Results The serum interleukin-6, 8, and 10 levels of patients in observed group were obviously lower than that in health group （P 〈 0.01）. After medical treatment, the serum interleukin-6, and 8 levels of patients in observed group had sharply declined, but serum interleukin-10 level had rose obviously than before （P 〈 0.05）. Coulusion There is existence of inflammatory cytokines in disorder in HDCP patients. The changes of the serum interleukin-6, 8, and 10 levels show the severity and change of disease of HDCP, which can be the evaluation index of the HDCP curative effect.
出处
《中国现代医生》
2013年第28期40-41,共2页
China Modern Doctor
基金
浙江省医学会临床科研基金(2011ZYCB05)
关键词
妊娠高血压疾病
白介素-6
白介素-8
白介素-10
Hypertensive disorder complicating pregnancy （HDCP）
Interleukin-6
Interleukin-8
Intcrleukin-10
