62例川崎病高敏C反应蛋白水平与静脉注射免疫球蛋白治疗敏感性分析

Sensitivity analysis of high-sensitivity C-reactive protein level in 62 cases of Kawasaki disease treatment with intravenous immunoglobulin

目的探讨川崎病患儿高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与使用静脉注射免疫球蛋白(intravenous immunoglobulin,IVIG)治疗敏感性的关系。方法将本科2008～2012年间就诊并使用免疫球蛋白治疗的62例川崎病患儿的高敏C反应蛋白检验值分为治疗前和治疗后两组,对比两组检验值的变化与使用免疫球蛋白治疗川崎病的敏感性之间是否有显著性差异。结果免疫球蛋白治疗有效的川崎病患儿的高敏C反应蛋白检验值显著下降,但免疫球蛋白无反应型川崎病患儿高敏C反应蛋白无明显下降,经统计学计算后有显著差异(P<0.01)。结论高敏C反应蛋白是检测川崎病活动性的敏感指标,有助于分析判断川崎病对静脉注射免疫球蛋白治疗的敏感性。

Objective To study the relationship between high-sensitivity C-reactive protein and the treatment of Kawasaki disease with intravenous immunoglobulin. Methods Sixty-two cases, admitted to hospital with Kawasaki dis- ease from 2008 to 2012 were tested for high-sensitivity C-reactive protein in Kawasaki disease before and after the treatment of the use of intravenous immunoglobulin. Whether there was a significant difference in contrast sensitivity between the two sets of test values change with the use of intravenous immunoglobulin in treatment of Kawasaki disease. Results High-sensitivity C-reactive protein test value of intravenous immunoglobulin is effective in the treatment of Kawasaki disease were decreased obviously,but no reaction of intravenous immunoglobulin in children with Kawasaki disease of high-sensitivity C-reactive protein showed no significant decrease. Conclusion High-sensitivity C-reactive protein is a sensitive indicator to detect the activity of Kawasaki disease, helps to analyze the sensitivity of judgments of intravenous immunoglobulin treatment of Kawasaki disease.