重症手足口病患儿心肌酶、肌钙蛋白Ⅰ和超敏C-反应蛋白检测的临床意义

Clinical significance of testing myocardial enzyme, troponin Ⅰ and hs-CRP on children with severe hand-foot-mouth disease

目的 探讨心肌酶、肌钙蛋白Ⅰ（cTn Ⅰ）和超敏C-反应蛋白（hs-CRP）检测在重症手足口病患儿中的临床意义.方法 选取2011年1月～2012年6月株洲市中心医院重症手足口病患儿43例为观察组,同时选取普通手足口病患儿56例作为对照组,分别检测两组血清心肌酶、cTn Ⅰ及hs-CRP的水平；并分析观察组患儿治疗前后这些指标的变化情况.结果 观察组心肌酶、cTn Ⅰ及hs-CRP高于对照组,差异有高度统计学意义（P＜0.01）.观察组患儿治疗后心肌酶、cTn Ⅰ、hs-CRP水平较治疗前明显下降,差异有高度统计学意义（P＜0.01）.结论 手足口病病程中心肌较易受到侵犯,心肌酶、cTn Ⅰ及hs-CRP检测的临床意义重大,可作为重症手足口病患儿心肌是否受损的一项常规指标.

Objective To explore the clinical significance of testing myocardial enzyme, cTn Ⅰ and hs-CRP on children with severe hand-foot-mouth disease. Methods 43 eases with severe hand-foot-mouth disease from January 2011 to June 2012 in the Central Hospital of Zhuzhou City were selected as the observation groupand 56 cases of regular hand-foot-mouth disease were chosen as the control group; the level of serum myocardial enzyme, cTn Ⅰ and hs-CRP in the two groups were tested, the indicators in observation group before and after the treatment were analyzed. Results The level of myocardial enzyme, cTn Ⅰ and hs-CRP in observation group were higher than those in control group, the differences were statistically significant （P 〈 0.01）. The level of myocardial enzyme, cTn Ⅰ and hs-CRP in observation group after the treatment were lower than those before the treatment, the differences were statistically significant （P 〈 0.01）. Conclusion It is easy for hand-foot-mouth disease to invade the myoeardinm, and testing myocardial enzyme, cTn Ⅰ and hs-CRP is of great clinical significance, and it is right to consider the index as the conventional examination.