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促血小板生成素与辐射损伤 被引量：1

Thrombopoietin and radiation injury
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摘要 TPO(促血小板生成素 )是巨核系造血的主要刺激因子 ,近年的研究表明 ,TPO与造血干细胞之间存在密切联系。TPO可促进辐射损伤后的造血重建 ,有可能解决急性放射病中血小板恢复滞后的问题。TPO在造血干细胞移植。 Thrombopoietin (TPO) is the primary regulator of megakaryocytopoiesis. Recent studies show that there is close relationship between TPO and hematopoietic stem cell. TPO can stimulate hematopoietic recovery after radiation injury. TPO may have widespread use in such areas as hematopoietic stem cell transplantation, platelets collection and separation.
作者 张军权 张浩
机构地区 北京放射医学研究所
出处 《国外医学（放射医学核医学分册）》 2000年第4期173-177,共5页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 促血小板生成素 辐射损伤 造血干细胞 thrombopoietin radiation injury hematopoietic stem cell
分类号 R14 [医药卫生—公共卫生与预防医学]
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参考文献10

  • 1Neelis KJ,Dubbelman YD,Wognum AW,et al.Lack of efficacy of thrombopoietin and granulocytecolonystimulating factor after high dose total -body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys[].Experimental Hematology.1997
  • 2Alexander WS.Thrombopoietin and the c-Mpl receptor : insights from gene targeting[].International Journal of Biochemistry Cell Biology The.1999
  • 3Mouthon MA,Vandamme M,Gourmelon P,et al.Preferential liver irradiation enhancies hematopoiesis through a thrombopoietin-independent mechanism[].Radiation Research.1999
  • 4Hokom MM,Lacey D,Kinstler OB,et al.Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice[].Blood.1995
  • 5Fibbe WE,Heemskerk DP,Laterveer L,et al.Accelerated reconstitution of platlets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice[].Blood.1995
  • 6Kaushansky K,Lin N,Chossmann A,et al.Thrombopoietin expands erythroid, granulocyte macrophage,and megakaryocytic progenitor cells in normal and myelosuppressed mice[].Experimental Hematology.1996
  • 7Kaushansky K.Thrombopoietin and the hematopoietic stem cell[].Blood.1998
  • 8Cohen-Solal K,Villeval JL,Titeux M,et al.Constitutive expression of mpl ligand transcripts during thrombocytopenia or thrombocytosis[].Blood.1996
  • 9Neelis KJ,Visser TP,Dimjati W,et al.A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short -term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells[].Blood.1998
  • 10Neelis KJ,Dubbelman YD,Qingliang L,et al.Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platlet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells[].Experimental Hematology.1997

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国外医学（放射医学核医学分册）
2000年 第4期

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