无限稀释摩尔电导对离子导入的影响

The effect of limiting molar conductivity on drug iontophoresis

目的 研究药物的无限稀释摩尔电导 (Λ0 )与离子导入速率的关系。方法 以盐酸丁卡因、盐酸普鲁卡因、盐酸达克罗宁、盐酸利多卡因和盐酸布比卡因等五种局麻药为模型药物 ,采用去毛大鼠腹部皮肤和双室扩散池 ,分别测定它们的无限稀释摩尔电导、经皮离子导入透皮速率 ,计算增渗倍数 (ER)。结果 以盐酸丁卡因、盐酸普鲁卡因、盐酸达克罗宁、盐酸利多卡因的ER对Λ0 回归得 :ER =- 76 .49+1.0 45× 10 -2 Λ0 (r=0 .9998)。按上述方程预测盐酸布比卡因的ER值 ,同实验非常接近。结论 无限稀释摩尔电导与离子导入增渗倍数成正比。

OBJECTIVE To study the effect of limiting molar conductivity(Λ 0)on drug iontophoresis.METHOD Dicaine hydrochloride ,procaine hydrochloride,dyclocaine hydrochloride,lidocaine hydrochloride and bupivacaine hydrochloride were used as model drugs .The enhancing rate(ER)of model drugs through rat skin were determined respectively using valia chien two chamber diffusion cells.RESULTS Linear regression of four drugs (dicaine hydrochloride、procaine hydrochloride、dyclocaine hydrochloride and lidocaine hydrochloride)showed that ER=-76.49+1.045×10 -2 Λ 0 (r=0.9998).According to this equation,The ER of bupivacaine hydrochloride was 14.2.It was very close to the ER of bupivacaine hydrochloride determined in experiment (ER=14).CONCLUSION The limiting molar conductivity is proportion to enhancing rate.