冠心病患者血浆纤维蛋白原与hs-CRP及血脂检测的临床意义

Clinical significance of detection of plasma fibrinogen and high sensitivity C-reactive protein in coronary heart disease

目的探讨血浆纤维蛋白原(FIB)与超敏C反应蛋白(hs-CRP)、血脂在冠心病诊疗中的价值。方法回顾性分析我院收治的98例冠心病患者与60例正常人群的临床资料,比较两组中血浆FIB、hs-CRP以及血脂水平的差异,以及3者与冠心病严重程度的关系。结果冠心病组中LDL-C水平均高于正常组,差异有统计学意义(P<0.05)。冠心病组的急性心肌梗死(AMI)与不稳定性心绞痛(UAP)的FIB、hs-CRP水平均高于正常组,差异有统计学意义(P<0.05),稳定性心绞痛(SAP)与正常组差异无统计学意义(P>0.05)。与正常组相比较,血管病变支数越多,FIB、hs-CRP、LDL-C的水平越高,差异有统计学意义(P<0.05)。结论通过检测FIB、hs-CRP能够判断疾病严重程度,对诊断及预后判断有重要价值。

Objective To investigate the value of detection of plasma fibrinogen （FIB） and high sensitivity C-reactive protein （hs-CRP） in coronary heart disease. Methods Detected the levels of the FIB and hs-CRP of 98 cases with coronary heart disease and 60 cases of normal physical examination in our hospital, and analyzed the relationship among the FIB, hs- CRP expressions and the seriousness of coronary heart disease. Results The LDL-C level of coronary heart disease group was significantly higher than that of the control group （P〈0.05）. The FIB and hs-CRP levels of acute myocardial infarction （AMI） and unstable angina pectoris （UAP） in CHD group were significantly higher than that of the control group （P〈0.05） ; these fig- ures were no difference in unstable angina（SAP） compared to the control group（P〉0.05）; compared to the control group, FIB and higher hs-CRP levels were significantly higher in multi-vessel disease （P〈0.05）. Conclusion The detection of FIB and hs-CRP levels can judge the seriousness of the disease, and is valuable for diagnosis and prognosis.