地佐辛全麻苏醒期过度镇痛的研究

Dezocine recovery from general anesthesia excessive analgesia

目的探讨地佐辛注射液全麻苏醒期过度镇痛疗效的研究。方法择期拟在全麻下行腹腔镜手术100例、开胸开腹手术100例、脊柱四肢手术100例，分别设定为A、B、C三组。性别不限，年龄20～60岁，体重指数21～27kg／m2，ASA分级I～Ⅱ级。采用随机数字表法将A组分为A1、A2；B组分为B1、B2；C组分为C1、C2。其中A1、B1、C1为对照组，A2、B2、C2为实验组，实验组术毕前30min静脉注射稀释至10ml的地佐辛10min，实验组给予生理盐水10ml，实施实验者未知任何实验信息，术毕填写调查表。以上实验患者均采用统一全麻诱导和维持药品与方法。结果通过问卷调查，使用地佐辛组患者术后发生烦躁、主诉疼痛的例数明显减少，呼吸抑制、恶心呕吐的发生未见明显增多。结论地佐辛可明显减轻全麻苏醒期患者疼痛，未见明显不良反应。

Objective Explore dezocine injection recovery from general anesthesia excessive analgesic efficacy studies. Methods Elective anesthesia proposed 100 cases of laparoscopic surgery, were set to A, B, C three groups. Male or female, age 20~60 years old, BMI 21~27kg / m, ASA grade Ⅰ-Ⅱ grade. Using a random number table was divided into group A, A1, A2; B group was divided into B1, B2; C group was divided into C1, C2. where A1, B1, C1 for the control group, A2, B2, C2 for the experimental group. Experimental group, 30 minutes before surgery intravenous injection diluted to 10ml of dezocine 10 mg, the experimental group received saline 10ml, the implementation of any experiment the experimenter unknown information, fill out the survey surgery. These patients were uniform experimental induction and maintenance of anesthesia drugs and methods. Results Through questionnaires, group of patients with postoperative dezocine irritability, complained of pain significantly reduced the number of eases, respiratory depression, nausea and vomiting was no significant increase. Conclusion Dezocine general anesthesia can significantly reduce the pain of patients, no significant side effects.