骨化三醇冲击治疗尿毒症继发性甲状旁腺功能亢进的效果分析

The effect analysis of calcitriol impulse therapy in the treatment of uremia secondary hyperparathyroidism

目的分析骨化三醇冲击治疗尿毒症继发性甲状旁腺功能亢进的疗效。方法将2011年2月～2013年1月本院尿毒症继发性甲状旁腺功能亢进患者83例纳入研究,根据患者意愿分为A、B组,均接受低钙透析治疗,在此基础上A组患者接受骨化三醇常规治疗,B组患者接受骨化三醇冲击治疗。连续治疗8周,对比两组患者血清钙(Ca)、磷(P)和甲状旁腺激素(PTH)指标和不良反应的差异性。结果与A组比较,B组患者血清Ca、P、PTH水平较低,不良反应发生率较低,差异有统计学意义(P<0.05)。结论采用骨化三醇冲击治疗尿毒症继发性甲状旁腺功能亢进的疗效和安全性具有一定的优越性,值得临床推广应用。

Objective To analyze the effect of calcitriol impulse therapy in the treatment of uremia secondary hyper- parathyroidism.Methods 83 uremia patients with secondary hyperparathyroidism in our hospital collected from Febru- ary 2011 to January 2013 were divided into group A and group B according to their own wills.All patients were treated with low calcium dialysis,on the basis of which,group A received conventional calcitriol therapy,and group B received ealcitriol impulse therapy.All patients were treated continuously for 8 weeks;the indexes of serum calcium （Ca）,phos- phorus （P）,parathyroid hormone （PTH）,and the difference of adverse reactions were compared with each group.Results Compared with group A,the levels of serum Ca,P,PTH and the rate of adverse reaction in group B were much lower, with significant difference （P〈0.05）.Condusion Calcitriol impulse therapy has certain efficacy and safety in the treat- ment of uremia secondary hyperparathyroidism,and it deserves applying extends.