高压氧治疗新生儿缺氧缺血性脑病78例疗效观察

Observation on effect of hyperbaric oxygenation on 78 hypoxic ischemic encephalopathy(HIE)of newborns

对 78例新生儿缺氧缺血性脑病 (HIE)给予高压氧加综合治疗 ,存活病例随访至 1～ 4岁。采用国内CDCC量表测定智商及神经系统检查 ,复查头颅 CT。对照组 62例 ,仅给综合治疗。结果发现 :高压氧组中、重度 HIE患儿神经症状消失平均时间短于对照组 (P<0 .0 1) ;两组总有效率比较 ,有显著性差异 (P<0 .0 1)。早期高压氧治疗发生脑损害较对照组明显减少 (P<0 .0 1) ,预后不良率低于对照组 (P<0 .0 5) ;晚期高压氧治疗的远期疗效与对照组比较 ,无显著性差异 (P>0 .0 5)。认为高压氧可明显缩短中、重度 HIE患儿病程 ,早期高压氧治疗可降低病死率、减少后遗症的发生及严重程度 ;晚期高压氧治疗对重症患儿不能改善预后。

WT5”BZ]78 hypoxic ischemic encephalopalhy(HIE)of newborns were treated with hyperbaric oxygenation(HBO)plus general therapy,and survivors were followed up until 1～4 years old,using the CDCC temperament scales to estimate IQ and examining nervous system,rechecking with CT(62 cases as control group were only given general therapy) The result showed that the average nervous symptoms disappearing time of moderate,severe HIE children in HBO group was shorter than that of control group(P<0 01),and the total effective between the two groups were statistically significant(P<0 01) Using hyperbaric oxygenation early,cerebral injury significantly decreased(P<0 01) and rate of bad prognosis was less than that of control group(P<0 05);but using lately,Long term effect was not significant(P>0 05) In general,the course of moderate,severe HIE was shortened after HBO therapy HBO therapy early the fatality rate of HIE and the morbidity degree of sequelae could be reduced;using lately the prognosis of severe cases could not be improved [WT5”HZ]