摘要
AIM To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS DL -NBP and D -NBP 20 mg·kg -1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L -NBP 20 mg·kg -1 showed no obvious effect. CONCLUSION The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.
AIM To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS DL -NBP and D -NBP 20 mg·kg -1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L -NBP 20 mg·kg -1 showed no obvious effect. CONCLUSION The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.
出处
《药学学报》
CSCD
北大核心
2000年第10期790-792,共3页
Acta Pharmaceutica Sinica
基金
国家科委1035工程重大项目!基金 (94 ZD 0 1)
国家自然科学基金!重大项目基金资助 (2 9790 12 2 )
关键词
丁基苯酞
脑缺血
神经细胞凋亡
钙凋磷酸酶
n-butylphthalide
transient focal cerebral ischemia
neuronal apoptosis
calcineurin
calpain
