多发性骨髓瘤遗传学演化及克隆异质性研究进展：2013年欧洲血液学会年会报道

Genetic evolution and heterogeneity of multiple myeloma： a report from the 2013 EHA annual meeting

研究发现意义未明的单克隆免疫球蛋白血症（MGUS）和冒烟型骨髓瘤（SMM）是多发性骨髓瘤（MM）的前期阶段。MGUS、SMM与MM具有相似的遗传学改变，如染色体易位、染色体数目异常、体细胞突变等。文章旨在讨论MM疾病演变阶段常见的遗传学演化及克隆异质性。

Recent studies have shown that multiple myeloma （MM） is preceded by a premalignant state called monoclonal gammopathy of undetermined significance （MGUS） and smoldering multiple myeloma （SMM）. Some of the genetic changes of MM are also present in MGUS and SMM, including chromosomal translocations, copy number changes, somatic mutations and so on. This article discusses the genetic heterogeneity.